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Not all patients respond to GLP-1 medications in the same way, and researchers are still working to understand why some people experience little or no effect

[2] [3] However, in April 2025, Pfizer announced it would abandon further development of danuglipron due to unpredictable liver toxicity

Histamine, an abundant pre-formed mediator, promotes vasodilation and increased capillary permeability that aids in the recruitment of immune cells to the site of inflammation (Riley and West, 1952)